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KMID : 0358419920350081160
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Korean Journal of Obstetrics and Gynecology
1992 Volume.35 No. 8 p.1160 ~ p.1169
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Estrogen and Progesterone Receptors in the Human Fallopian Tubes
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박영자/Park YJ
송찬호/손인숙/조동제/Song CH/Sohn IS/Cjo DJ
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Abstract
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It is known that uterine tubal smooth muscle contraction is mainly controlled by estrogen & progesterone, but until recently, studies regarding estrogen and progesterone receptor concentrations present in fallopian tubes have been rare. This study evaluated the estrogen and progesterone levels in the isthmic and ampullar portions of normal tubes from 21 patient to investigate the estrogen and progesterone receptor concentrations according to different anatomical portion of the fallopian tubes and also according to menstrual cycle and after menopause. And obtained following results after analysing these data. 1. The mean estrogen and progesterone receptor concentrations in the cytoplasm in the ampullar portion was higher than in the isthmic portion, and also higher in the proliferative phase than in the secretory phase or a post-menopausal state. The estrogen and progesterone concentration in the isthmic portion during the proliferative phase was significantly higher than in the isthmic portion of the post-menopausal state.(P<0.05). And the progesterone receptor concentration in the ampulla portion during proliferative phase was significantly higher than in the ampulla portion of the secretory phase (P<0.05). 2. The mean estrogen and progesterone receptor concentrations in the nucleus in the ampullar portion was higher than in the isthmic portion was higher than in the isthmic portion, and also higher the proliferative phase than in the secretory phase or the post-menopausal state. According to these results, the estrogen and progesterone receptor concentrations were higher in the ampullar portion than in the isthmic portion, and also these levels were higher during the proliferative phase than in the secretory phase or post-menopausal state. We therefore conclude that evaluation of normal estrogen and progesterone receptor concentrations and of the difference according to different anatomical portions and different phase of the menstual cycle could be benefit as basic data for studying the relationship between these concentrations and tubal segmental perostaltic movement, and for studying factors which cause abnormal uterine peristaltic movement in cases such as infertility caused by tubal factors.
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KEYWORD
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